Fig. 3

Summary view of the potential therapeutically targetable somatic alterations. The data matrix shows the targetable pathogenic somatic variants detected in relapsed tumors (Pz). Mutated genes are reported by row, and samples are reported by column. On the top of the matrix, we reported the patient characteristics (gender, disease stage, MYCN amplification status and the age at diagnosis; Gt18 age at diagnosis ≥ 18mo, Lt18 age at diagnosis < 18mo). The matrix is split by rows based on the involved pathways (source: MyCancerGenome). The annotation track on the right reports the level of priority of the variant based on the pathogenicity and actionability (see Methods). TMB*: Tumor Mutational Burden. High TMB was considered if the patient had more than five variants per megabase of sequencing target regions