Fig. 1

Results of multiomics analysis. A GO enrichment analysis (left) and KEGG enrichment analysis (right) of mutated genes in the PT group. The color of the bubble indicates the -log10 (p value) of the GO term or KEGG pathway, and the size of the bubble signifies the number of genes associated with a term. B t-SNE representing 35,949 cells from 14 types of peripheral blood. C Heatmap displaying expression levels of 13 target genes in platelets from the two groups. D Prioritization of cell types related to thrombosis using Augur. A high area under the curve (AUC) indicates high sensitivity of the cells to changes in thrombosis. E Dot plot showing expression levels of differentially expressed genes (DEGs) in myeloid cells from the two groups. F Number of DEGs associated with a term from GO enrichment analysis of myeloid cells. G Heatmap displaying expression levels of differentially expressed proteins (DEPs) from the two groups. H GO enrichment analysis of DEPs between the PT and P groups. I Heatmap displaying the protein expression level of 18 DEPs in four samples. J Pathway diagram of platelet activation. The red border represents upregulated plasma proteins in the PT group, and the red/green filled box represents upregulated/downregulated genes in the PT group