Fig. 3

IMPDH2 expression is upregulated in CRC patients and is associated with multiple drug resistance. A IMPDH2 expression in various types of cancer in the TIMER database. B The mRNA expression of IMPDH2 in 24 matched CRC and adjacent noncancerous samples from the GSE10950. The protein expression of IMPDH2 in CRC based on sample types (C), individual cancer stages D and histological subtypes E from CPTAC. F The IMPDH2 protein expression from HPA database. GSEA was performed to showing a significant association between the IMPDH2 expression and the PURINE_METABOLISM G and MULTIPLE-DRUG-RESISTANCE H. **p < 0.01, and ***p < 0.001