Table 1 Evaluation of biochemical parameters of the three experimental animal groups: Control (C), MCT group, and MCT-siRNA AP-1 group, after 4 respectively 12 weeks of MCT injection to induce pulmonary arterial hypertension
After 4 weeks of MCT injection/2 weeks of siRNA AP-1 treatment | Control group (n = 12) | MCT group (n = 14) | MCT-siRNA AP-1 group (n = 13) |
|---|---|---|---|
Glycaemia (mg/dl) | 150.29 ± 35.4 | 165.43 ± 28.4 | 143.78 ± 19.4 |
Cholesterol (mg/dl) | 203.58 ± 30.3 | 181.74 ± 14.6 | 162.63 ± 23.3 |
Triglyceride (mg/dl) | 204.22 ± 26.6 | 340.89 ± 54.5 | 214.52 ± 25.6 |
HDL cholesterol (mg/dl) | 70.56 ± 11.5 | 64.73 ± 11.8 | 66.66 ± 14.9 |
LDL cholesterol (mg/dl) | 81.8 ± 8.65 | 80.41 ± 9.3 | 87.71 ± 15.8 |
Hepatic transaminases (U/L) | |||
 AST | 84.72 ± 3.72 | 89.57 ± 4.8 | 92.97 ± 4.4 |
 ALT | 78.45 ± 1.7 | 80.21 ± 4.0 | 84.91 ± 2.6 |
After 12 weeks of MCT injection/10 weeks of siRNA AP-1 treatment | Control group (n = 12) | MCT group (n = 14) | MCT-siRNA AP-1 group (n = 13) |
|---|---|---|---|
Final body weight (g) | 121.42 ± 11.9 | 107.66 ± 10.3 | 110.64 ± 11.8 |
Heart weight (g) | 0,49 ± 0.05 | 0.98 ± 0.10 ***P < 0.005 | 0.65 ± 0.06 ##P < 0.01 |
Glycaemia (mg/dl) | 136.45 ± 19.9 | 160.19 ± 28.2 | 139.92 ± 19.7 |
Cholesterol (mg/dl) | 177.69 ± 14.6 | 190.70 ± 18.4 | 164.09 ± 16.1 |
Triglyceride (mg/dl) | 225.23 ± 25.1 | 430.83 ± 85.9 ***P < 0.005 | 173.45 ± 44.1 ###P < 0.005 |
HDL cholesterol (mg/dl) | 60.37 ± 11.6 | 71.75 ± 6.1 | 60.25 ± 7.8 |
LDL cholesterol (mg/dl) | 72.20 ± 17.1 | 88.83 ± 9.5 | 77.61 ± 12.3 |
Hepatic transaminases (U/L) | |||
 AST | 100.43 ± 6.6 | 100.83 ± 5.8 | 100.18 ± 3.9 |
 ALT | 93.94 ± 8.6 | 95.16 ± 4.9 | 97.22 ± 4.1 |