Fig. 5

Representative transmission electron microscopy (TEM) images showing the effect of the 12-week administration of MCT alone or in combination with siRNA AP-1 (for 10 weeks) on: A the pulmonary artery; B lung parenchyma; C right ventricle of hamsters from each of the three experimental groups. EC endothelial cell, SMC vascular smooth muscle cell, IEL internal elastic lamina, BL basal lamina, ECM extracellular matrix, col, collagen fibres, el elastin, N nucleus, m mitochondria, cav caveolae, Gc Golgi complex, rER rough endoplasmic reticulum (ER*: stressed ER), mvb multivesicular bodies, PMN polymorphonuclear leukocyte, PL platelet, f myofilaments, AEC 1 type 1 alveolar epithelial cell, AEC 2 type 2 alveolar epithelial cell, RBC red blood cell, MF macrophage, IF inflammatory cell, IS interstitial space, IC interstitial cell, LD lipid droplet, LB surfactant-storing lamellar bodies, tm tubular myelin, Gg glycogen granules, TC telocyte, SR sarcoplasmic reticulum, #: large vacuoles; yellow ellipse: contact between a leukocyte and the endothelial cell surface; dashed yellow boxes: regions with fragmented elastin; arrows: dense plaques; yellow freehand line: alveolar-capillary fused basement membrane; yellow boxes: intercalated discs. Scale bars indicate from left to right and top to bottom: A 2 µm, 0.5 µm; 1 µm, 0.5 µm, 1 µm / 0.5 µm; 1 µm, 0.25 µm; B 1 µm, 1 µm, 0.5 µm; 1 µm, 1 µm, 1 µm; 1 µm, 1 µm, 1 µm; C 2 µm, 1 µm, 1 µm; 1 µm, 1 µm, 1 µm; 1 µm, 1 µm, 1 µm