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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: The siRNA-mediated knockdown of AP-1 restores the function of the pulmonary artery and the right ventricle by reducing perivascular and interstitial fibrosis and key molecular players in cardiopulmonary disease

Fig. 2

The development of pulmonary arterial hypertension in hamsters exposed to MCT for 12 weeks and siRNA AP-1 for 10 weeks compared to control animals. A Systolic blood pressure (mmHg), B diastolic blood pressure (mmHg) and C Heart Rate (bpm) of pulmonary arteries were measured using non-invasive voltage device and data quantification. For each measurement, the average value of a continuous recording interval (8–10 times) was calculated. Five animals from each experimental group were evaluated. The data represent the means ± SD. Statistical significance represented as ***P < 0.005, versus control group and ###P < 0.005, ##P < 0.01 versus MCT group. One-way ANOVA, Bonferroni post-test was applied. D–F Representative waveforms of pulmonary arterial pressure in all three experimental animal groups: systolic blood pressure (left-red), diastolic blood pressure (right-red), heart rate (blue)

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Journal of Translational Medicine

ISSN: 1479-5876

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