Fig. 1

Schematic illustration of experimental animal models obtained for a period of 12 weeks. Golden Syrian hamsters (39 males, 3 months old) were randomly divided into three experimental groups, including: (1) C group, healthy animals; (2) MCT group obtained by a single subcutaneous injection dose of 60 mg/kg monocrotaline (MCT) at the beginning of the experiment (day 0); (3) MCT-siRNA AP-1 group that received subcutaneous injections of 100 nM siRNA AP-1 every two weeks. All animal groups received water and standard chow ad libitum