Fig. 7

In vivo validation demonstrated that PITPNC1 orchestrates the upregulation of CD155 via FASN in radioresistant tumors, leading to immune evasion. A Graph of weight variation in animal models. B Statistical chart of subcutaneous tumor volume in mice. C, D Comparison of protein expression levels of Ki67, PITPNC1, FASN, CD155 and CD8 in mouse tissues through immunohistochemistry. E, F Immunofluorescence analysis of the proportion of IFN-γ⁺ CD8⁺ T cells in tumor tissues. G Analysis of the proportion of CD8⁺ T cells in the tumor tissues using flow cytometry. Data indicate the mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001, by 2-tailed Student’s t test or one-way ANOVA. N = 5