Fig. 2

MEG3 can inhibit the proliferation of ovarian cancer cells. A Expression levels of MEG3 in normal ovarian epithelial cell lines and ovarian cancer cell lines. B, C qRT‒PCR was used to verify the construction of MEG3 knockdown (A2780) and overexpression (SKOV3) cell lines. D CCK-8 assay of NC, MEG3 knockdown, and MEG3 overexpression cells. E Colony formation assay of NC, MEG3 knockdown, and MEG3 overexpression cells. F Cell cycle analysis of NC, MEG3 knockdown, and MEG3 overexpression cells. G Apoptosis analysis of NC, MEG3 knockdown, and MEG3 overexpression cells. H Expression level of caspase-3, cleaved caspase-3, PARP1, and cleaved PARP1 in NC, MEG3 knockdown, and MEG3 overexpression cells. I DNA synthesis assay of NC, MEG3 knockdown, and MEG3 overexpression cells. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001