Fig. 5
From: Tirzepatide prevents neurodegeneration through multiple molecular pathways
Tirzepatide induces upregulation of main glucose transporters in neuronal cells: A GLUT1, B GLUT3, C GLUT4, and D SORBS1 mRNA expression levels in SHSY5Y cells (left panel). The fold increase of mRNA expression compared with NG was calculated using the 2−ΔΔCt method. Western Blot analysis of GLUT1 (A), GLUT3 (B), GLUT4 (C) and SORBS1 (D) (right panel). The histograms show the densitometric analysis of 3 separate experiments representing the relative expression being NG value set as 1. Data are mean ± SEM. *p < vs NG; **p < vs HG