Fig. 2
From: Tirzepatide prevents neurodegeneration through multiple molecular pathways
Tirzepatide increases the growth markers expression in neuronal cells exposed to HG: A CREB and B BDNF mRNA expression levels in SHSY5Y cells (left panel). The fold increase of mRNA expression compared with NG was calculated using the 2−ΔΔCt method. Western Blot analysis of CREB (A) and BDNF (B) (right panel). The histograms show the densitometric analysis of 3 separate experiments representing the relative expression being NG value set as 1. Data are mean ± SEM. *p < vs NG; **p < vs HG