Fig. 6

Single-cell cohort of HCC patients showing low-RGPRG score HCC patients possess an immune-active state. A t-SNE plot of the seven cell clusters derived from HCC samples. B t-SNE plot showing the distribution of RGPRG score in seven cell clusters. C Boxplot of RGPRG score in ten HCC samples. D Differential number of interactions (left) and strength (right) of seven cell clusters between high- and low-RGPRG score. E Number of inferred interactions (left) and strength (right) of seven cell clusters between high- and low-RGPRG score. F Circos plots of the putative ligand-receptor interactions between TNK cell and other cell clusters. Each brand points to interacting cell cluster. G Circos plots of the putative ligand-receptor interactions between B cell and other cell clusters. Each brand points to an interacting cell cluster. H Signaling pathway circle plots and network showing MIF signaling pathway between high- and low-RGPRG score groups. I Signaling pathway circle plots and network showing MK signaling pathway between high- and low-RGPRG score groups