Fig. 3

Construction and validation of Rho GTPase-related gene signature in the HCC cohort. A The coefficients of selected features in the LSSSO regression model. B Partial likelihood deviance of selected features in the LSSSO regression model. C Multivariate logistic regression analysis shows that ARHGAP11A, IQGAP3, KIF18A, and SFN are independently associated with prognosis (P < 0.05). D–F K–M curve showing the low-RGPRG score group had better survival than the high-RGPRG score group in TCGA-LIHC, GSE76427, ICGC-LIRI-JP cohorts. G–I The receiver operation characteristic (ROC) curve of the Rho GTPase-related gene signature to predict 1-, 3-, and 5-year survival in TCGA-LIHC, GSE76427, ICGC-LIRI-JP cohorts