Fig. 2

Identifying molecular subtypes of HCC based on 44 candidate Rho GTPase-related genes. A Consensus clustering cumulative distribution function (CDF) for k = 2 to 6. B When K = 2, the relative change in area under the CDF curve was optimal. C consensus clustering identified two clusters. D Principal component analysis (PCA) of cluster 1 and cluster 2. E Kaplan–Meier (KM) survival analysis of cluster 1 and cluster 2, and cluster 1 had better survival compared with cluster 2. F Heatmap of differential expression genes between two clusters. G Cluster 1 had a higher proportion of TNM stage I than cluster 2. H Cluster 1 had a higher proportion of Grade 1 and 2 than cluster 2. I Cluster 1 had a higher proportion of male than cluster 2. *P < 0.05