Table 4 Hazard ratios of the genetic alterations under investigation obtained by multivariate Cox regression models with backward elimination
Feature | HR | 95% CI | p-value |
|---|---|---|---|
Mutated (m)KRAS | – | – | – |
Surgery | 0.1238 | 0.0508 to 0.3020 |  < 0.0001 |
Adjuvant therapy | – | – | – |
T | – | – | – |
N | 2.7091 | 1.1919 to 6.1575 | 0.0170 |
M | – | – | – |
mBRAF (nonV600) mNRAS (uncommon) | – | – | – |
Surgery | 0.1238 | 0.0508 to 0.3020 |  < 0.0001 |
Adjuvant therapy | – | – | – |
T | – | – | – |
N | 2.7091 | 1.1919 to 6.1575 | 0.0170 |
M | – | – | – |
mPIK3CA | – | – | – |
Surgery | 0.1238 | 0.0508 to 0.3020 |  < 0.0001 |
Adjuvant therapy | – | – | – |
T | – | – | – |
N | 2.7091 | 1.1919 to 6.1575 | 0.0170 |
M | – | – | – |
mCDKN2A | – | – | – |
Surgery | 0.1238 | 0.0508 to 0.3020 |  < 0.0001 |
Adjuvant therapy | – | – | – |
T | – | – | – |
N | 2.7091 | 1.1919 to 6.1575 | 0.1700 |
M | – | – | – |
mTP53 | – | – | – |
Surgery | 2.7091 | 1.1919 to 6.1575 |  < 0.0001 |
Adjuvant therapy | – | – | – |
T | – | – | – |
N | 2.7091 | 1.1919 to 6.1575 | 0.1700 |
M | – | – | – |
mSMAD4 | 2.4987 | 1.0134 to 6.1607 | 0.0467 |
Surgery | 0.0891 | 0.0331 to 0.2397 |  < 0.0001 |
Adjuvant therapy | – | – | – |
T | – | – | – |
N | 3.4631 | 1.4461 to 8.2934 | 0.0053 |
M | – | – | – |
mPOLE / mPOLD1 | – | – | – |
Surgery | 2.7091 | 1.1919 to 6.1575 |  < 0.0001 |
Adjuvant therapy | – | – | – |
pT | – | – | – |
pN | 2.7091 | 1.1919 to 6.1575 | 0.1700 |
M | – | – | – |
mMMR genes | 2.5218 | 0.8906 to 7.1406 | 0.0815 |
Surgery | 0.0814 | 0.0278 to 0.2379 |  < 0.0001 |
Adjuvant therapy | – | – | – |
T | – | – | – |
N | 3.5458 | 1.4546 to 8.6434 | 0.0054 |
M | – | – | – |
mDR genes | 3.0126 | 1.0707 to 8.4764 | 0.0367 |
Surgery | 0.0957 | 0.0306 to 0.2998 | 0.0001 |
Adjuvant therapy | 0.3642 | 0.1100 to 1.2057 | 0.0980 |
T | – | – | – |
N | 0.2280 | 1.7129 to 10.4365 | 0.0180 |
M | – | – | – |
Mutation load rate | 1.0018 | 1.0005 to 1.0032 | 0.0090 |
Surgery | 0.1417 | 0.0510 to 0.3933 | 0.0002 |
Adjuvant therapy | 0.2807 | 0.0750 to 1.0498 | 0.0590 |
T | – | – | – |
N | 3.4240 | 1.2897 to 9.0905 | 0.0140 |
M | – | – | – |