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Table 2 Hazard ratios of the genetic mutations under investigation obtained by log-rank test

From: Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population

Mutated genes

HR

95% CI

p-value

KRAS

1.2337

0.5509 to 2.7627

0.610

BRAF (nonV600) NRAS (uncommon)

2.0720

0.7344 to 5.8458

0.170

PIK3CA

0.4734

0.2129 to 1.0525

0.066

CDKN2A

1.2823

0.5525 to 2.9763

0.560

TP53

0.4730

0.2084 to 1.0736

0.073

SMAD4

1.1467

0.5033 to 2.6130

0.740

POLE / POLD1

0.7953

0.3472 to 1.8213

0.590

MMR genes

0.8510

0.3763 to 1.9246

0.700

DR genes

0.8795

0.3999 to 1.9344

0.750

Mutation Load Rate

0.5953

0.2553 to 1.3878

0.230

  1. HR, hazard ratio; CI, confidence interval; MMR, mismatch repair; DR, damage repair
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Journal of Translational Medicine

ISSN: 1479-5876

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