Table 4 KEGG pathways involved in the Retinitis Pigmentosa mechanistic map with mapped the RP-genes

MAPK signaling pathway

hsa04010

KRAS

ErbB signaling pathway

hsa04012

KRAS

Ras signaling pathway

hsa04014

KRAS

Rap1 signaling pathway

hsa04015

KRAS

cGMP-PKG signaling pathway

hsa04022

CNGB1, CNGA1, GTF2I, GTF2IRD1

cAMP signaling pathway

hsa04024

CNGB1, CNGA1

Chemokine signaling pathway

hsa04062

KRAS

HIF-1 signaling pathway

hsa04066

HK1

FoxO signaling pathway

hsa04068

KRAS

Sphingolipid signaling pathway

hsa04071

KRAS

Phospholipase D signaling pathway

hsa04072

KRAS

mTOR signaling pathway

hsa04150

KRAS

PI3K-Akt signaling pathway

hsa04151

KRAS

Apoptosis

hsa04210

KRAS

Longevity regulating pathway—mammal

hsa04211

KRAS

Hedgehog signaling pathway

hsa04340

SUFU

Axon guidance

hsa04360

SEMA4A, KRAS, LIMK1

VEGF signaling pathway

hsa04370

KRAS

Tight junction

hsa04530

KRAS

Gap junction

hsa04540

GJA1, KRAS

Signaling pathways regulating pluripotency of stem cells

hsa04550

KRAS

Natural killer cell mediated cytotoxicity

hsa04650

KRAS

T cell receptor signaling pathway

hsa04660

KRAS

B cell receptor signaling pathway

hsa04662

KRAS

Fc epsilon RI signaling pathway

hsa04664

KRAS

Fc gamma R-mediated phagocytosis

hsa04666

LIMK1

Neurotrophin signaling pathway

hsa04722

KRAS

Cholinergic synapse

hsa04725

KRAS

Serotonergic synapse

hsa04726

KRAS

GABAergic synapse

hsa04727

GABRD

Regulation of actin cytoskeleton

hsa04810

KRAS, LIMK1

Insulin signaling pathway

hsa04910

HK1, KRAS

GnRH signaling pathway

hsa04912

KRAS

Progesterone-mediated oocyte maturation

hsa04914

KRAS

Estrogen signaling pathway

hsa04915

KRAS

Melanogenesis

hsa04916

KRAS

Prolactin signaling pathway

hsa04917

KRAS

Thyroid hormone signaling pathway

hsa04919

KRAS

Oxytocin signaling pathway

hsa04921

KRAS

Aldosterone-regulated sodium reabsorption

hsa04960

KRAS