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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery

Fig. 6

Histological study of selected targets in retinas sections of rd10 mice, murine model of Retinitis Pigmentosa. Confocal micrographs of transverse sections through rd10 mice retina. DAPI nuclear staining illustrating the retinal cytoarchitecture (retinal inner nuclear layer INL, retinal inner plexiform layer IPL, retinal outer nuclear layer ONL, retinal outer plexiform layer OPL and retinal ganglion cell layer GCL). Photoreceptor degeneration (A, B), and retinal distribution of selected KDTs KCC2 (C, D), GABARα1 (E, F) and NR1 (G, H) in control and rd10 mice at P23. The Mann–Whitney test was used to compare control “C” and rd10 mice. Scale bar: 50 µm. *p < 0.05. All data were presented as the mean ± standard error of the mean (SEM). We analyzed at least four retinas for each group and age

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