Fig. 2

Overview of the RP mechanistic map viewer in the Hipathia Web tool. The RP mechanistic map is composed of 226 circuits belonging to 40 pathways. The Estrogen signaling pathway is shown as a selection example. Colors represent RP genes found to be associated with the disease in OMIM/ORPHANET (Blue) or to be related to the disease phenotypes in HPO db (green). The shape of the edge indicates the type of interaction (activation/inhibition) between circuit nodes. The left tab above the main panel enables the selection/search of specific proteins on the selected pathway, while the right tab allows the option to export as an SVG image the visualized pathway