Fig. 4

Relationship between BMI-associated intestinal flora and infiltrating immune cells in CRC. A Bar graph of relative abundance of immune cells in CRC patients grouped by BMI status. Each bar represents a sample, and each color in the graph corresponds to a type of immune cell. The ordinate is the relative abundance value of immune cells, and the sum of the relative abundance of all immune cells in a single sample is 1. B Heat maps of correlation between dominant colonies in the Normal weight group and tumor-infiltrating immune cells. C Heat maps of correlation between dominant colonies in the Overweight group and tumor-infiltrating immune cells. The horizontal coordinates are immune cells and the vertical coordinates are bacteria. Red indicates a positive correlation and blue indicates a negative correlation. The depth of the color indicates the size of the Pearson correlation coefficient, and the color from light to dark indicates the value of the phase relationship from small to large. The “*” in the graph represents the size of the P-value: No * for P-value ≥ 0.05, * for 0.01 ≤ P < 0.05, ** for 0.001 ≤ P < 0.01, *** for P < 0.001. D Network diagram of correlations between intestinal microbiota and immune cell differences associated with BMI. Nodes in different colors in the figure represent intestinal flora and immune cells respectively, and the connection lines between nodes indicate significant correlation between nodes. The blue line indicates that the Spearman correlation coefficient is less than 0 (negative correlation), while the red line indicates that the Spearman correlation coefficient is greater than 0 (positive correlation)