Fig. 3
FBXW7 overexpression inhibits the stem cell-like properties of TNBC cells. A Pearson’s correlation coefficient analysis of the correlation analysis between FBXW7 and mRNAsi in TCGA-BRCA datasets (r = − 0.08082, p = 0.0081). B FBXW7 expression was detected in spheres and their adherent TNBC cells by Western blotting. C Representative images and quantitative analysis of spheres. Scale bar: 100 mm. D ALDEFLUOR assay of the percentage of ALDH-positive cells in different treatment groups. E FACS profiles and quantification of the CD44high/CD24low subpopulation. F Western blot analysis of the protein levels of stem cell markers (SOX2, OCT4, NANOG and EPCAM) in different cell treatment groups