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Table 2 The risk of incident type 2 diabetes upon exposure to cumulative MHR and cumulative hsCRP

From: Measurement of cumulative high-sensitivity C-reactive protein and monocyte to high-density lipoprotein ratio in the risk prediction of type 2 diabetes: a prospective cohort study

 

Combination of CumCRP and CumMHR, HRs (95% CIs)

 

CumCRP < 1 mg/L & CumMHR < 0.2340

1 ≤ CumCRP < 3 mg/L & CumMHR < 0.2340

CumCRP ≥ 3 mg/L & CumMHR < 0.2340

CumCRP < 1 mg/L & CumMHR ≥ 0.2340

1 ≤ CumCRP < 3 mg/L & CumMHR ≥ 0.2340

CumCRP ≥ 3 mg/L & CumMHR ≥ 0.2340

Event/Total

527/7743

1003/8564

500/4099

522/5177

1251/8848

1045/6382

Incidence rate

9.32

16.48

17.40

14.33

20.38

23.94

Unadjusted model

Reference

1.78 (1.60–1.98)

1.87 (1.66–2.12)

1.53 (1.35–1.73)

2.18 (1.97–2.42)

2.57 (2.31–2.85)

Model 1

Reference

1.53 (1.38–1.70)

1.48 (1.30–1.67)

1.43 (1.26–1.61)

1.78 (1.60–1.97)

1.88 (1.69–2.10)

Model 2

Reference

1.43 (1.29–1.59)

1.42 (1.27–1.63)

1.32 (1.16–1.49)

1.55 (1.39–1.72)

1.71 (1.52–1.91)

Model 3

Reference

1.26 (1.11–1.42)

1.10 (0.91–1.34)

1.35 (1.20–1.53)

1.41 (1.24–1.60)

1.35 (1.12–1.63)

Model 4

Reference

1.41 (1.27–1.57)

1.39 (1.23–1.58)

1.12 (0.97–1.30)

1.31 (1.15–1.48)

1.43 (1.25–1.64)

Model 1

0.65 (0.59–0.73)

Reference

Reference

0.97 (0.87–1.08)

0.93 (0.84–1.04)

1.16 (1.07–1.27)

1.23 (1.13–1.34)

Model 2

0.70 (0.63–0.78)

 

1.01 (0.90–1.12)

0.93 (0.84–1.04)

1.11 (1.02–1.21)

1.22 (1.11–1.34)

Model 1

0.56 (0.51–0.62)

0.86 (0.79–0.94)

0.83 (0.75–0.92)

0.80 (0.72–0.89)

Reference

1.06 (0.97–1.15)

Model 2

0.65 (0.58–0.72)

0.92 (0.84–1.01)

0.92 (0.83–1.03)

0.85 (0.77–0.95)

Reference

1.10 (1.01–1.20)

Model 1

0.53 (0.48–0.59)

0.81 (0.74–0.89)

0.78 (0.70–0.87)

0.76 (0.68–0.84)

0.95 (0.87–1.02)

Reference

Model 2

0.58 (0.52–0.66)

0.84 (0.76–0.92)

0.84 (0.75–0.93)

0.77 (0.69–0.86)

0.91 (0.83–0.99)

Reference

  1. P-interaction: CumMHR (< median or ≥ median) * CumCRP (< 1, 1 to 3, or ≥ 3 mg/L) = 0.0278; CumMHR (< median or ≥ median) * log(CumCRP) < 0.0001
  2. Model 1: adjusted for age (continuous), sex, education, smoking status, drinking status, physical activity, family history of diabetes, and BMI (categorical);
  3. Model 2: Model 1 + FBG (continuous), hypertension (categorical), logTG (continuous), LDL-C (continuous), eGFR (categorical), antihypertensives (yes or no), lipid-lowering drugs (yes or no), and log(leukocyte) (continuous);
  4. Model 3: Model 2 + logCumCRP;
  5. Model 4: Model 2 + logCumMHR. Abbreviations as Table 1
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Journal of Translational Medicine

ISSN: 1479-5876

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