First author, year | Study design | Vitamin D assessment | Vitamin D adjusted per season | N. of patients | TTO | Comparison modalities | Other biomarkers evaluated | MINORS score | NOS score | RoB2 assessment |
---|---|---|---|---|---|---|---|---|---|---|
Ng, 2011 | P | RIA | Yes | 515 | OS, PFS | Interquartile comparison, lowest ≤ 13.1 ng/mL vs highest ≥ 27.2 ng/mL) | No | 7 | 7 | NA |
Obermannova, 2015 | P | EBA | Yes | 84 | OS, PFS | Normal vs Low (cutoff: 40 nmol/L) | CEA | 7 | 5 | NA |
Golubić, 2017 | P | EBA | No | 72 | OS, PFS | No supplementation vs Supplementation (2000 UI/die) For two years Measurement in nmol/L* | No | NA | NA | Some concerns |
Ng, 2019 | P | RIA | No | 139 | OS, PFS | High dose supplementation (8000 IU/die for the cycle 1, then 4000 IU/die) vs Standard dose (400 UI/die) Chronic administration Measurement in ng/mL** | No | NA | NA | Low risk |
Yuan, 2019 | P | RIA | Yes | 1041 | OS, PFS | Interquintile comparison, lowest ≤ 10.8 ng/mL vs highest ≥ 24.1 ng/mL | No | 7 | 6 | NA |