Fig. 5

Best-corrected visual acuity and refraction progression of unilateral high myopia. Different colored points represent different genes, gray points represent patients without an identified genetic cause, and the red curve represents the best nonlinear fit of all data points. Scatter plots show the steady improvement of best-corrected visual acuity with age in the highly myopic eye (A) and the fellow eye (C). The other scatter plots show the gradual progression of refraction with age in the highly myopic eye (B) and the fellow eye (D). E Paired box plot showing the mean visual acuity of highly myopic eye improving from 0.84 to 0.56 logMAR (P = 4.3E−5) with clinical intervention over 6–12 months (38 patients). F Mean visual acuity of highly myopic eyes improved from 0.72 to 0.39 logMAR (P = 0.003) with clinical intervention in the period from 18 to 24 months (20 patients). G. Mean visual acuity improved from 0.53 to 0.40 with clinical intervention (P = 0.011) over periods from 6 to 12 months and 18 to 24 months (18 patients). H Comparison between the bassline visual acuity and final visual acuity at time points of 6–12 months and 18–24 months after clinical intervention (18 patients). BCVA = best-corrected visual acuity, yrs = years, mo = month