Fig. 3

The molecular testing results and genetic landscape of the unilateral high myopia cohort. A Pedigrees of 20 unilateral families with potential pathogenic variants in 13 genes. The phenotypes of the patients shown in the pedigrees were based on the first visit. A solid black pattern indicates high myopia, a half-filled pattern indicated unilateral high myopia. a striped pattern indicates mild to moderate myopia. Circles represent females, squares represent males, and circles with a dot in center indicate heterozygous female carriers. M indicates mutant allele, + indicates the normal allele. Black arrows point to probands. B The molecular test results of 75 unrelated pedigrees with unilateral high myopia. Potential pathogenic variants in 13 genes were identified in 26.73% of the in-house cohort (20/75). C The distribution of the contributions of 13 genes to unilateral high myopia in these patients