Fig. 3

miR-218-5p overexpression inhibits the expression of IFN-I response related genes in the SN of MPTP-induced mice. A, B Volcano plots showing the DEGs in NC MPTP mice versus NC Control mice (A) and the DEGs in miR-218 MPTP mice versus NC MPTP mice (B). N = 3 per group. Data are shown as |Log2 (fold change)|≥ 0.585, p-value < 0.05. C Pheatmaps showing the top DEGs in NC MPTP mice versus NC Control mice and the top DEGs in miR-218 MPTP mice versus miR-218 Control mice. D qPCR analysis showing mRNA expression of several IFN-I related genes (Irf7, Nlrc5, Ddx60) in the SN of NC Control, NC MPTP, miR-218 Control and miR-218 MPTP mice. N = 5–6 per group. Data are shown as the mean ± SEM. Significance was tested by two-way ANOVA. *p < 0.05, **p < 0.01