Fig. 6
Effects of FO on hypertensive retinopathy and dysfunction in Ang II-infused mice retina. A The mice were treated with FO (300 mg/kg/day) one day before Ang II infusion one day before Ang II infusion, and then once/day for 3 weeks. B SBP of each group was recorded (n = 6). C Images of H&E staining of central retinal sections (left), the thickness was quantified (n = 6). D DHE staining of retina in each group (left), the quantification of DHE intensity (n = 6). E Typical retinal angiograms and fundus photos (left), these white arrows indicate vascular fluorescein leakage and the corresponding area in the fundus photo. The ratio of retinal arteriovenous and fluorescence intensity was quantified (right; n = 6). F qPCR analyses of inflammatory mRNA of Il6 and Tnf (n = 6). G qPCR analyses of oxidative stress mRNA of Nox1 and Nox4 (n = 6)