Fig. 3

Ang II-induced pyroptosis depend on NLRP3 inflammasome activation. A qPCR analyses of Nlrp3 and Il1b mRNA in retina (n = 6). B The expression of NLRP3, IL-1β and IL-1β p17 protein levels. C The quantification of protein expression (n = 4). D Immunohistochemical staining of NLRP3 in retina (left), quantification of NLRP3 positive area (right, n = 6). *P < 0.05, **P < 0.01, ***P < 0.0001 vs control; ^#P < 0.05, ^##P < 0.01 vs Ang II group