Fig. 1

Ang II-induced SIRT1 decrease and overexpression of NLRP3 inflammasome. A Mice were infused with Ang II (3000 ng/kg/min) or saline for 3 weeks. qPCR analyses of Sirt1, Nlrp3 and Il1b mRNA in retina (n = 6). B The expression of SIRT1, NLRP3, IL-1β and IL-1β p17 protein levels. C The quantification of protein expression (n = 4). *P < 0.05, **P < 0.01 vs control