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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Fig. 5

ACSS2 regulated the PI3K/AKT/mTOR pathway and then regulated lipid metabolism reprogramming. A Overexpression of ACSS2 activated the PI3K/AKT/mTOR pathway. B Knockdown of ACSS2 suppressed the PI3K/AKT/mTOR pathway. C Lipid droplets reduced after rapamycin-treated. D, E Triglycerides and total cholesterol reduced after rapamycin-treated (F). Free fatty acids increased after rapamycin-treated. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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