Fig. 1

Hypoxia upregulated ACSS2, which is highly expressed in pNENs. A–C qRT-PCR and WB indicated that hypoxia upregulated ACSS2 expression in pNENs cells. D CUT-RUN showed increased binding of HIF-1a to ACSS2 after hypoxia in pNENs cells. E EGA database showed higher ACSS2 expression in pNENs tumor tissues than pNENs paraneoplastic tissues. F, G, H qRT-PCR, WB and immunofluorescence indicated that ACSS2 expression was higher in pNENs cells than in HPNE. *p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001