Fig. 4
From: MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B
MiR-93-5p targets on KDM6B and influences H3K27me3 marks. A The H3K27me3 mark was down-regulated during the odontogenic differentiation of hDPSCs. B–E MiR-93-5p mimic decreased KDM6B and induced H3K27me3 marks during the odontogenic differentiation of hDPSCs. F After miR-93-5p mimic treatment, H3K27me3 demethylases were suppressed while H3K27me3 methylases were no significantly different. G Dual-luciferase assay confirmed that miR-93-5p targeted on the 3’ UTR of KDM6B. H MiR-93-5p mimic treatment down-regulated the expression level of BMP2 in hDPSCs after odontogenic induction. ns, not significant. *P < 0.05, **P < 0.01 and ***P < 0.001