Fig. 5
Mapping of TCRβ associated with S epitopes as resulted from GLIPH2 analysis. a Median clonal fraction refers to the median of clonotype frequencies from the individual pre-stimulation repertoires. Dimension of bubbles correlates with the number of distinct clonotypes associated with the epitope. b Glimpse of panel A highlighting the S regions (overlapping epitopes) associated to TCRβ differentially abundant between COVID-19 groups. C TCR binding prediction of S peptides from original Wuhan-Hu-1 strain and VOCs variants. The distinct TCRβ sequences associated with the indicated S peptide (Table 3) were evaluated in-silico for predicted binding affinity by the ERGO tool (Mann Whitney test)