Fig. 4

Inference of TCRβ clonotypes specificity by GLIPH analysis (a) Network analysis of the most significant (Fisher score < 10^–4) specificity groups annotated with TCRβ sequences from NV (red), V (green), and VDJdb/MIRA (blue) datasets. Each dot is a specificity group, edges indicate the presence of identical TCRβ sequence(s) shared across two specificity groups. b Shared number of S-epitopes in VDJdb/MIRA, V and NV groups. c, d Characteristics of a representative clustered specificity group, including a representation of amino acid sequence alignment of both the multiple TCRβ in the cluster (c), and the associated S region (d)