Fig. 1
From: MTFR2-dependent mitochondrial fission promotes HCC progression
A The mitochondrial dynamic paradigm. Mitochondria undergo dynamic changes in shape by the two opposite processes of fission and fusion. Mitochondrial fusion of the outer membrane is mediated by MFNs. Fusion of the inner mitochondrial membrane is regulated by OPA1. Mitochondrial fission requires DRP1 phosphorylation and recruitment. In HCC, impaired mitochondrial dynamic equilibrium induces tumor proliferation, drug resistance, metastasis, and stem properties. B Flow chart of construction and validation of a prognostic signature for LIHC. MFNs mitofusins, OPA1 optic atrophy 1, DRP1 dynamin-related protein 1, HCC hepatocellular carcinoma. LIHC liver hepatocellular carcinoma