Improved cognition after rifaximin treatment is associated with changes in intra- and inter-brain network functional connectivity

Table 5 Significant correlations between remarkable inter-network functional connections and neuropsychological tests or blood biochemical parameters

Connection	Psychometric tests	R	p value
Medial visual network and Thalamic network	PHES	0.723	0.01
	DST (items completed)	0.788	0.006
	NCT-B (seconds)	− 0.778	0.008
	LTT (seconds + errors)	− 0.57	0.047
	Stroop-neutral task	0.666	0.022
	Stroop-incongruent task	0.669	0.022
	Bimanual coordination (min)	− 0.892	0.002
	d2 test-TR values	0.627	0.047
	d2 test-TA values	0.638	0.046
	d2 test-TOT values	0.681	0.03
	d2 test-CON values	0.62	0.047
	Oral SDMT (correct pairings)	0.753	0.009
	Oral SDMT (total pairings)	0.731	0.01

Connection	Biochemical parameters	R	p value
Medial sensorimotor network and Dorsal attention network	IL18	0.581	0.041
Medial sensorimotor network and Dorsal attention network	CXCL13	0.633	0.033
Right fronto-parietal network and Supramarginal gyrus network	IL6	− 0.633	0.035
	IL18	− 0.774	< 0.001
	IL15	− 0.59	0.043

R and p from significant Spearman correlations are shown. R, correlation coefficient. Correlations were considered significant at p < 0.05 after FDR correction

ISSN: 1479-5876