Improved cognition after rifaximin treatment is associated with changes in intra- and inter-brain network functional connectivity

Table 4 Significant correlations between remarkable intra-network functional clusters and neuropsychological tests or blood biochemical parameters

Network	Cluster	Psychometric tests	R	p value
Left fronto-parietal network	LFPN-1	PHES	− 0.595	0.046
		DST (items completed)	− 0.583	0.046
		NCT-A (seconds)	0.708	0.015
		Oral SDMT (correct pairings)	− 0.668	0.019
		Oral SDMT (total pairings)	− 0.6	0.019
	LFPN-2	PHES	− 0.7	0.015
		DST (items completed)	− 0.683	0.019
		LTT (seconds + errors)	0.597	0.029
		Stroop-neutral task	− 0.644	0.02
		Stroop-incongruent task	− 0.592	0.034
		Oral SDMT (correct pairings)	− 0.769	0.013
		Oral SDMT (total pairings)	− 0.704	0.015
Lateral sensorimotor network	LSMN-1	DST (items completed)	− 0.69	0.018
Lateral sensorimotor network	LSMN-1	Oral SDMT (correct pairings)	− 0.669	0.018

Network	Cluster	Biochemical parameter	R	p value
Left fronto-parietal network	LFPN-1	IL6	0.66	0.019
	LFPN-2	IL6	0.815	< 0.001
		IL18	0.565	0.026
		Mip3/CCL20	0.59	0.024
		IL22	0.656	0.01
Lateral sensorimotor network	LSMN-1	IL6	0.663	0.009
		IL18	0.524	0.046
		IL22	0.755	0.002
		IL15	0.511	0.046
		Fractalkine/CX3CL1	0.519	0.046
	LSMN-2	IL6	0.68	0.017
		IL18	0.824	< 0.001
		Mip3/CCL20	0.711	0.017
		CXCL13	0.66	0.018
		IL22	0.607	0.032
		IL15	0.689	0.017
Medial sensorimotor network	MSMN-1	Ammonia	0.55	0.03
		IL6	− 0.709	0.003
		IL22	− 0.715	0.003
		IL15	− 0.597	0.021

R and p from significant Spearman correlations are shown
R, correlation coefficient. Correlations were considered significant at p < 0.05 after FDR correction
Clusters are named as shown in Table 3

ISSN: 1479-5876