Table 3 Intra-network clusters showing significant changes and notable trends
Observed effect | Affected network | Cluster name | N voxels | p value | MNI (X, Y, Z) | Location |
|---|---|---|---|---|---|---|
General effect of rifaximin | ||||||
 Increase of signal after treatment | Medial sensorimotor network | MSMN-1 | 5 | 0.01 | − 8, 18, 2 | Left Caudate |
 Decrease of signal after treatment | Right fronto-parietal network | RFPN-1 | 1 | 0.096 | − 30, − 62, 30 | Left intraparietal 0 area (IP0) |
Left fronto-parietal network | LFPN-1 | 11 | 0.02 | − 20, − 40, 58 | Left Brodmann area 2 | |
LFPN-2 | 4 | 0.034 | 4,− 52,− 12 | Right cerebellar lobule I-IV | ||
LFPN-3 | 2 | 0.051 | − 28,− 52,62 | Left area 7 anterior lateral (7AL) | ||
LFPN-4 | 1 | 0.094 | 26,− 2,30 | Right superior corona radiata | ||
Lateral sensorimotor network | LSMN-1 | 1 | 0.021 | 12,− 30,54 | Right corticospinal tract | |
Effect of treatment exclusively on responding patients | ||||||
 Decrease of signal after treatment | Lateral sensorimotor network | LSMN-2 | 2 | 0.01 | 2,− 4,46 | Right area 24 prime posterior (p24pr) |
Left fronto-parietal network | LFPN-5 | 1 | 0.074 | 18,10,16 | Right caudate | |
LFPN-6 | 1 | 0.099 | 26,− 2,28 | Right superior corona radiata | ||
Interaction between treatment and response group | ||||||
 Relative increase of signal in Responder patients and Relative decrease of signal in Non-responder patients | Thalamic network | THN-1 | 10 | 0.021 | − 41,57,4 | Left area 9–46 anterior ventral (a9-46v) |
THN-2 | 2 | 0.086 | − 3,− 33,12 | Left Corpus callosum splenium | ||
Lateral visual network | LVN-1 | 1 | 0.089 | − 26,− 38,52 | Left Brodmann area 2 | |
Pre-existing differences between response groups | ||||||
 Increased signal in patients who will Respond | Basal ganglia network | BGN-1 | 39 | 0.014 | 2,− 54,28 | Right area 7 medial (7 M) |
BGN-2 | 4 | 0.06 | 18,− 52,32 | Right posterior corona radiata | ||