Fig. 4

Boxplots showing z scores of inter-networks connections with significant changes after rifaximin treatment. A–D Considering all patients as one group, before and after treatment. E–H Stratifying patients by response group (Resp: responding patients; NoResp: non-responding patients). Significant pre- and post-treatment differences were analysed using a general linear model similar to a paired t-test and are indicated by (*): *p < 0.05, **p < 0.01. Significant interactions between treatment and response group were analysed using a general linear model similar to a 2-way mixed effect ANOVA and are indicated by (α): α p < 0.05. All p values were corrected for multiple comparisons using FDR, and differences were considered significant at p < 0.05 after correction