Fig. 4
Tumor growth delay and control by neoVLP vaccinated animals. A Experimental design of a preventive protocol for the evaluation of tumor control. B Evaluation of cellular responses generated against the selected neoantigens and Gag peptides. C Tumor growth curves of each animal in the Tier2-GAG group in yellow. Animals vaccinated with naked-VLP are represented by grey dotted lines. D Tumor growth curves of each animal in the Tier2-GAG + MPLA group in brown. Animals vaccinated with naked-VLP are represented by grey dotted lines. E Kaplan–Meier graph representing the time before mice reach a tumor volume equal or over 500 mm3. Tier2-GAG in yellow, Tier2-GAG + MPLA in brown and naked-VLP in grey. F Kaplan–Meier graph representing the time before mice reach a tumor volume equal or over 500mm3. Vaccinated with Tier2-GAG in blue (with or without MPLA) and naked-VLP vaccinated mice in grey