Fig. 2
From: Post-translational protein lactylation modification in health and diseases: a double-edged sword
Lactate from extracellular matrix or glycolysis resulted in lactylation. A Lactate may synthesize lactyl-CoA, and then, the lactyl group is transferred by “writer” to lysine, leading to lactylation of histones or non-histones to affect gene expression or downstream signaling pathways. B Three types of interactions (in different color blocks) between lactylation (pink residues with La) and other PTMs (green residues with R) are shown