Fig. 7

Expression of GBP1, CD3, PD-1, PD-L1 and CK in 104 cervical cancer were detected using multiplexed immunofluorescence. A Representative costaining images of GBP1, CD3, PD-1, PD-L1 and CK in the GBP1 high and low expression. Scale bars: 100 µm. B Correlation between the GBP1 positive (GBP1+) percent (%) and CD3/PD-1/PD-L1 positive percent (%) in 104 CC. C Correlation between the CK+GBP1+ (%) and CD3+/PD-1+/PD-L1+ (%) in 104 CC. D Correlation between the CD3+GBP1+ (%) and CD3+PD-1+/CD3+PD-L1+ (%) in 104 CC. E Correlation between the CK+GBP1+ (%) and CK+PD-L1+ (%) in 104 CC. F Correlation between the CK+GBP1+ (%) and CD3+PD-1+/CD3+PD-L1+ (%) in 104 CC. G Survival analysis showing the relationship between CK+GBP1+/CK+ levels and the OS of patients in 104 CC patients. H The percentage of CK+GBP1+ cells in stage I&II and stage III&IV CC tissues were compared. CK+GBP1+ represents CC cells expressing GBP1. CD3+GBP1+ represents tumor infiltrating lymphocytes expressing GBP1. CK+GBP1+/CK+ (proportion of CK+GBP1+ in CK+) represents the proportion of GBP1 expressed CC cells in CC cells. CC cervical cancer, OS overall survival