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Table 2 MR estimates for the association between gut microbiota and survival of sepsis

From: Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology

Bacterial taxa (exposure)

MR method

NSNP

OR

L 95% CI

U 95% CI

p-value

Bacteroidia 912 class

IVW

14

1.4850

1.0691

2.0625

0.0183

MR Egger

14

1.2214

0.6043

2.4686

0.5877

Weighted median

14

1.4842

0.9351

2.356

0.0939

Weighted mode

14

1.4448

0.7893

2.6447

0.2543

Simple mode

14

1.1944

0.5386

2.6487

0.6691

Lentisphaeria 2250 class

IVW

8

0.6779

0.5311

0.8652

0.0018

MR Egger

8

0.7098

0.2859

1.7621

0.4879

Weighted median

8

0.7265

0.5314

0.993

0.0451

Weighted mode

8

0.8569

0.5109

1.4374

0.5769

Simple mode

8

0.8344

0.5005

1.3912

0.5101

FamilyXIII 1957 family

IVW

10

1.5632

1.0575

2.3105

0.0250

MR Egger

10

5.6288

1.4367

22.0535

0.0381

Weighted median

10

1.3089

0.7726

2.2175

0.3169

Weighted mode

10

1.0497

0.4102

2.6862

0.9217

Simple mode

10

1.0497

0.4431

2.4868

0.9147

Coprococcus1 11301 genus

IVW

12

0.6926

0.4992

0.9610

0.0279

MR Egger

12

0.5276

0.2429

1.1458

0.1371

Weighted median

12

0.8395

0.5241

1.3446

0.4666

Weighted mode

12

0.9983

0.4317

2.3085

0.9968

Simple mode

12

1.0094

0.4363

2.3355

0.9829

Coprococcus2 11302 genus

IVW

9

0.5390

0.3105

0.9358

0.0281

MR Egger

9

2.0173

0.0717

56.7457

0.6925

Weighted median

9

0.5847

0.3329

1.0271

0.0619

Weighted mode

9

0.4732

0.1710

1.3097

0.1879

Simple mode

9

0.4580

0.1524

1.3765

0.2017

Lachnospiraceae FCS020 genus

IVW

13

0.7375

0.5499

0.9891

0.0420

MR Egger

13

0.4264

0.2033

0.8946

0.0455

Weighted median

13

0.7537

0.5004

1.1351

0.1759

Weighted mode

13

0.8318

0.4409

1.5692

0.5800

Simple mode

13

0.9349

0.4437

1.9698

0.8625

Terrisporobacter 11348 genus

IVW

5

1.4337

1.0160

2.0231

0.0403

MR Egger

5

1.0294

0.4008

2.6442

0.9556

Weighted median

5

1.3120

0.8415

2.0454

0.2308

Weighted mode

5

1.3096

0.7862

2.1815

0.3588

Simple mode

5

1.3068

0.7591

2.2496

0.3889

Bacteroidales 913 order

IVW

14

1.4850

1.0691

2.0625

0.0183

MR Egger

14

1.2214

0.6043

2.4686

0.5877

Weighted median

14

1.4842

0.9295

2.3700

0.0981

Weighted mode

14

1.4448

0.8122

2.5699

0.2326

Simple mode

14

1.1944

0.5704

2.5013

0.6453

Victivallales 2254 order

IVW

8

0.6779

0.5311

0.8652

0.0018

MR Egger

8

0.7098

0.2859

1.7621

0.4879

Weighted median

8

0.7264

0.5321

0.9919

0.0443

Weighted mode

8

0.8569

0.5266

1.3946

0.5540

Simple mode

8

0.8344

0.4922

1.4147

0.5231

Lentisphaerae 2238 phylum

IVW

9

0.7209

0.5588

0.9300

0.0118

MR Egger

9

0.7852

0.2905

2.1224

0.6481

Weighted median

9

0.7947

0.5853

1.079

0.1409

Weighted mode

9

0.8711

0.5304

1.4305

0.6003

Simple mode

9

0.8577

0.5125

1.4353

0.5750

  1. IVW inverse variance weighted, MR Mendelian randomisation, NSNP number of single-nucleotide polymorphisms, OR odds ratio, L 95% CI lower 95% confidence interval, U 95% CI upper 95% confidence interval
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Journal of Translational Medicine

ISSN: 1479-5876

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