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Table 1 MR estimates for the association between gut microbiota and sepsis

From: Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology

Bacterial taxa (exposure)

MR method

NSNP

OR

L 95% CI

U 95% CI

p-value

Lentisphaeria 2250 class

IVW

8

0.8588

0.7812

0.9442

0.0017

MR Egger

8

0.7915

0.5705

1.0982

0.2113

Weighted median

8

0.8538

0.7510

0.7510

0.0158

Weighted mode

8

0.8858

0.7272

1.0789

0.2672

Simple mode

8

0.8720

0.7102

1.0706

0.2321

Clostridiaceae1 1869 family

IVW

10

1.2112

1.0447

1.4043

0.0111

MR Egger

10

1.6419

1.0782

2.5000

0.0496

Weighted median

10

1.1884

0.9729

1.4516

0.0908

Weighted mode

10

1.1289

0.7874

1.6186

0.5260

Simple mode

10

1.1265

0.8128

1.5613

0.4924

Eubacteriumeligens group 14372 genus

IVW

8

1.2841

1.0585

1.5579

0.0112

MR Egger

8

1.2694

0.5842

2.7582

0.5689

Weighted median

8

1.1017

0.8646

1.4038

0.4333

Weighted mode

8

1.0679

0.7756

1.4703

0.6994

Simple mode

8

1.0820

0.7202

1.6255

0.7155

Coprococcus2 11302 genus

IVW

9

0.8402

0.725

0.9736

0.0206

MR Egger

9

1.1628

0.4869

2.7768

0.7441

Weighted median

9

0.9008

0.734

1.1053

0.3168

Weighted mode

9

0.9140

0.6786

1.2311

0.5705

Simple mode

9

0.9140

0.6687

1.2493

0.5883

Dialister 2183 genus

IVW

11

0.8480

0.7416

0.9695

0.0158

MR Egger

11

0.9571

0.5600

1.6358

0.8762

Weighted median

11

0.8339

0.6991

0.9947

0.0435

Weighted mode

11

0.7639

0.5760

1.0132

0.0911

Simple mode

11

0.7609

0.5729

1.0106

0.0884

Gordonibacter 821 genus

IVW

12

1.0941

1.0148

1.1795

0.0191

MR Egger

12

0.9278

0.6738

1.2775

0.6559

Weighted median

12

1.0913

0.9839

1.2103

0.0984

Weighted mode

12

1.0011

0.8096

1.2380

0.9920

Simple mode

12

1.0073

0.8250

1.2299

0.9442

Lachnospiraceae ND3007 genus

IVW

3

1.3999

1.0405

1.8834

0.0263

MR Egger

3

0.9446

0.0064

138.9848

0.9857

Weighted median

3

1.3540

0.9313

1.9686

0.1125

Weighted mode

3

1.3457

0.8798

2.0584

0.3044

Simple mode

3

1.3446

0.9019

2.0046

0.3044

Lachnospiraceae UCG004 genus

IVW

14

0.8771

0.7706

0.9983

0.0471

MR Egger

14

0.6067

0.3628

1.0145

0.081

Weighted median

14

0.9568

0.8049

1.1375

0.617

Weighted mode

14

1.0086

0.7567

1.3443

0.9546

Simple mode

14

1.0086

0.7524

1.3518

0.9554

Ruminococcaceae UCG011 genus

IVW

8

1.1036

1.1035

1.2020

0.0237

MR Egger

8

1.1335

0.7243

1.7737

0.6032

Weighted median

8

1.0877

0.9657

1.2252

0.1658

Weighted mode

8

1.0582

0.8934

1.2534

0.5333

Simple mode

8

1.0656

0.8809

1.2891

0.5337

Victivallales 2254 order

IVW

8

0.8588

0.7812

0.9442

0.0017

MR Egger

8

0.7915

0.5705

1.098

0.2113

Weighted median

8

0.8538

0.7506

0.9712

0.0162

Weighted mode

8

0.8858

0.7225

1.0859

0.2814

Simple mode

8

0.8719

0.7125

1.0672

0.2255

Lentisphaerae 2238 phylum

IVW

9

0.8910

0.8001

0.9922

0.0354

MR Egger

9

0.8396

0.5525

1.2759

0.4399

Weighted median

9

0.8729

0.7722

0.9867

0.0296

Weighted mode

9

0.8921

0.7332

1.0855

0.2871

Simple mode

9

0.8796

0.7219

1.0718

0.2390

  1. IVW inverse variance weighted, MR Mendelian randomisation, NSNP number of single-nucleotide polymorphisms, OR odds ratio, L 95% CI lower 95% confidence interval, U 95% CI upper 95% confidence interval
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Journal of Translational Medicine

ISSN: 1479-5876

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