Fig. 5

NCAPG2 is positively correlated with c-MYC expression. a The bar plot showed there were 114 up-regulated and 49 down-regulated proteins between oe-NCAPG2 and oe-NC groups. b LC-MS/MS analysis revealed that protein level of c-MYC was significantly increased in the oe-NCAPG2 group. c The hierarchical cluster indicated that there were significant differences in protein expression pattern between oe-NCAPG2 and oe-NC groups. d Top 20 terms of KEGG results indicated the related pathways about NCAPG2. e GSEA showed the activity of c-MYC was positively related to NCAPG2 expression. f-h The expression of NCAPG2 and MYC was positively correlated based on TCGA dataset, GSE70769 dataset, and GSE116918 dataset. LC-MS liquid chromatography–mass spectrometry, KEGG Kyoto Encyclopedia of Genes and Genomes, GSEA Gene Set Enrichment Analysis, TCGA The Cancer Genome Atlas. P values were calculated by the Student’s t-test, and P < 0.05 is defined as statistically significant