Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial

Table 2 Effects of SAAR on body weight, body composition and resting metabolic rate¹

	4 weeks		8 weeks
	β (95% CI) SAAR vs. control	p-value	β (95% CI) SAAR vs. control	p-value
Body weight, kg	− 0.70 (− 1.6, 0.21)	0.13	− 1.14 (− 2.04, − 0.25)	0.013
BMI, kg/m²	− 0.19 (− 0.49, 0.12)	0.23	− 0.30 (− 0.60, 0.00)	0.049
Body fat, %	− 0.08 (− 0.66, 0.51)	0.79	0.01 (− 0.57, 0.59)	0.98
Total fat, kg	− 0.30 (− 1.01, 0.42)	0.41	− 0.40 (− 1.11, 0.31)	0.27
Arm fat, kg	− 0.03 (− 0.15, 0.09)	0.67	− 0.02 (− 0.14, 0.09)	0.68
Leg fat, kg	− 0.10 (− 0.39, 0.19)	0.50	− 0.15 (− 0.44, 0.14)	0.31
Trunk fat, kg	− 0.13 (− 0.67, 0.40)	0.62	− 0.20 (− 0.73, 0.33)	0.46
Android fat, kg	0.01 (− 0.10, 0.13)	0.80	− 0.05 (− 0.17, 0.06)	0.38
Gynoid fat, kg	− 0.03 (− 0.16, 0.10)	0.66	− 0.12 (− 0.26, 0.01)	0.060
Visceral adipose tissue, kg	0.05 (− 0.03, 0.14)	0.21	0.02 (− 0.06, 0.11)	0.57
Subcutaneous adipose tissue, kg	− 0.03 (− 0.13, 0.07)	0.55	− 0.08 (− 0.17, 0.02)	0.12
Fat free mass, kg	– 0.38 (− 0.87, 0.12)	0.13	− 0.69 (− 1.18, − 0.20)	0.013
Resting metabolic rate, kcal/d	57.1 (− 19.4, 134)	0.14	15.2 (− 60.4, 90.7)	0.69
Fat oxidation, g/day	20.0 (1.82, 38.2)	0.031	12.8 (− 5.12, 30.7)	0.16
Carbohydrate oxidation, g/day	− 21.5 (− 58.3, 15.3)	0.25	− 17.9 (− 54.2, 18.3)	0.33
Respiratory quotient	− 0.01 (− 0.03, 0.01)	0.20	− 0.01 (− 0.03, 0.01)	0.22

¹ β-estimates and p-values are derived from linear mixed models with body mass as the outcome, and group, visit and their interaction term (group × time) at 4 and 8 weeks as predictors. The models were baseline adjusted. The p-value indicates the difference between groups at each timepoint. BMI body mass index, SAAR sulfur amino acid restriction

ISSN: 1479-5876