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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway

Fig. 8

MiR-410-5p prevents LPS-induced abortion in mice. A Schematic diagram of animal experiment design and procedures. B Embryonic development of mice in each group on GD13·5 days. C The effect of agomir-410-5p on embryo quality before or after LPS infection. D HE staining was used to analyze the inflammatory injury of heart, liver, lung, kidney and small intestine in each group. E Simple Western was used to detect the expression of STAT1 proteins in the uterine tissue of mice (n = 3). F IHC was used to detect the expression and distribution of STAT1 proteins in the uterine tissue of mice (n = 3). Values were listed as the mean ± SEM. Ns not significant, * P < 0·05, **P < 0·01, ****P < 0·0001

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