Fig. 1
Clinical value of mir-410-5p in early pregnancy. A Volcano plot of differential expressed miRNA (|log2 (foldchange)|> 1 and adjusted p < 0.05). B Partial differential miRNA expression in decidual macrophages of induced abortion and recurrent abortion was verified by qRT-PCR. C The expression of miR-410-5p in decidua and villus of normal pregnancy and spontaneous abortion was detected using qRT-PCR. D–H The expression level of miR-410-5p in plasma and its diagnostic value. D qRT-PCR was used to analyze the expression of miR-410-5p in plasma of non-pregnant women (n = 17), early pregnant women (n = 31), threatened abortion group (n = 29) and spontaneous abortion group (n = 30). E ROC analysis of the diagnostic value of miR-410-5p in early pregnancy (early pregnancy vs non-pregnancy). F ROC analysis of the diagnostic value of miR-410-5p in spontaneous abortion (spontaneous abortion vs early pregnancy). G ROC analyzed the predictive value of miR-410-5p on spontaneous abortion (spontaneous abortion vs threatened abortion). H ROC analyzed the predictive value of miR-410-5p on threatened abortion (threatened abortion vs early pregnancy). Values were listed as the mean ± SEM. *P < 0·05, ***P < 0·001, ****P < 0·0001