Fig. 1

AIM2 upregulation is highly detected in primary tumors compared to normal adjacent tissues and correlates with a poor response to radiotherapy in OSCC. A and B Boxplots and dot plots with line respectively present AIM2 mRNA levels in the unpaired normal tissues (N)/primary tumors (T) and paired normal adjacent tissues (NAT)/primary tumors derived from TCGA HNSCC (A) and GSE4273 OSCC (B) samples. C and D RT-PCR (C) and dot plots with lines (D) show the AIM2 gene expression in the paired primary tumors/normal adjacent tissues derived from OSCC samples in Taipei Medical University (TMU) Biobank. E Kaplan–Meier analyses for AIM2 mRNA levels using overall survival (OS) probability under a maximal risk condition against TCGA HNSCC (upper) and GSE42743 OSCC (lower) patients who received radiotherapy. F Scatchard plots for the correlation between AIM2 mRNA levels in the respective primary tumors and overall survival time of TCGA HNSCC and GSE42743 OSCC patients receiving radiotherapy (RT) with the overall survival endpoint as alive or dead