Fig. 7
From: EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression
EXO1 promoted lipid synthesis and progression in prostate cancer by inhibiting P53 signaling. A In prostate cancer cells with knockdown of EXO1, P53 was further knocked down. EXO1, P53, and SREBP1 were detected using Western blot. B–D In the above cells, the proliferative ability of the cells was detected using CCK-8 and EdU assays. E In the above cells, the metastatic ability of the cells was determined us transwell assays. F–G In the above cells, lipid droplets were labeled using oil red O staining, and triglyceride, and cholesterol content was measured